Assay Detail
Functional
CHEMBL707264
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Inhibition of growth (cytotoxicity) of L1210 cell line in vitro
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Novel fluorinated antifolates. Enzyme inhibition and cytotoxicity studies on 2'- and 3'-fluoroaminopterin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 8.72 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL18925 | — | — | 1 | 9.00 |
| CHEMBL376180 | AMINOPTERIN | 2.0 | 1 | 8.74 |
| CHEMBL19227 | — | — | 1 | 8.64 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 8.49 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL18925 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL376180 | AMINOPTERIN | EC50 | = | 1.8 | nM | 8.74 |
| CHEMBL19227 | — | EC50 | = | 2.3 | nM | 8.64 |
| CHEMBL34259 | METHOTREXATE | EC50 | = | 3.2 | nM | 8.49 |