Assay Detail
Functional
CHEMBL707294
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Inhibition of the growth of methotrexate resistant L1210 leukemia/R 81 cells in culture
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Comparison of the biological effects of selected 5,8-dideazafolate analogues with their 2-desamino counterparts.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.27 | 4.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL139551 | — | — | 1 | 4.41 |
| CHEMBL171480 | — | — | 1 | 4.12 |
| CHEMBL354121 | — | — | 1 | - |
| CHEMBL422395 | — | — | 1 | - |
| CHEMBL171790 | — | — | 1 | - |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | - |
| CHEMBL138870 | — | — | 1 | - |
| CHEMBL169376 | — | — | 1 | - |
| CHEMBL36739 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL139551 | — | IC50 | = | 39000.0 | nM | 4.41 |
| CHEMBL171480 | — | IC50 | = | 75000.0 | nM | 4.12 |
| CHEMBL354121 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL422395 | — | IC50 | = | 116000.0 | nM | - |
| CHEMBL171790 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 186000.0 | nM | - |
| CHEMBL138870 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL169376 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL36739 | — | IC50 | > | 200000.0 | nM | - |