Assay Detail
Functional
CHEMBL707295
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of the growth of methotrexate sensitive L1210 leukemia/S cells in culture
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Comparison of the biological effects of selected 5,8-dideazafolate analogues with their 2-desamino counterparts.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.23 | 8.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 8.36 |
| CHEMBL171480 | — | — | 1 | 6.57 |
| CHEMBL354121 | — | — | 1 | 6.55 |
| CHEMBL169376 | — | — | 1 | 6.28 |
| CHEMBL139551 | — | — | 1 | 5.92 |
| CHEMBL171790 | — | — | 1 | 5.89 |
| CHEMBL422395 | — | — | 1 | 5.85 |
| CHEMBL36739 | — | — | 1 | 5.50 |
| CHEMBL138870 | — | — | 1 | 5.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL34259 | METHOTREXATE | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL171480 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL354121 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL169376 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL139551 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL171790 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL422395 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL36739 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL138870 | — | IC50 | = | 7600.0 | nM | 5.12 |