Assay Detail

CHEMBL707296

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Functional

Compound was evaluated for cytotoxic activity on L1210 murine leukemia cells

ChEMBL ↗

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Target

L1210 (CHEMBL386) ↗

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Primary target L1210

CHEMBL386

Anchored from Assay target.

Protein identity L1210

Disease frame Disease evidence pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Mus musculus
Cell Type	L1210
Confidence	1 — Organism
Curated By	Intermediate

Target

L1210 (CHEMBL386) ↗

Type	CELL-LINE
Organism	Mus musculus

Publication

BN 80245: An E-ring modified camptothecin with potent antiproliferative and topoisomerase I inhibitory activities

Lavergne O, Lesueur-Ginot L, Rodas FP, Bigg DC
Bioorg Med Chem Lett (1997) 7 : 2235 -2238
· DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	3	6.97	7.79

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL72832	—	—	1	7.79
CHEMBL65	CAMPTOTHECIN	-1.0	1	6.90
CHEMBL84	TOPOTECAN	4.0	1	6.22

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL72832	—	IC50	=	16.2	nM	7.79
CHEMBL65	CAMPTOTHECIN	IC50	=	126.0	nM	6.90
CHEMBL84	TOPOTECAN	IC50	=	601.0	nM	6.22