Assay Detail
Functional
CHEMBL707297
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In vitro cytotoxicity against L1210 murine leukemia cells
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Phenyl sulfur mustard derivatives of distamycin A.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.67 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL545422 | — | — | 1 | 9.05 |
| CHEMBL541291 | — | — | 1 | 8.54 |
| CHEMBL553635 | — | — | 1 | 8.02 |
| CHEMBL543303 | — | — | 1 | 7.69 |
| CHEMBL542105 | — | — | 1 | 7.22 |
| CHEMBL545612 | TALLIMUSTINE CHLORIDE | — | 1 | 7.16 |
| CHEMBL852 | MELPHALAN | 4.0 | 1 | 6.01 |
| CHEMBL541041 | — | — | 1 | - |
| CHEMBL542354 | — | — | 1 | - |
| CHEMBL539768 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL545422 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL541291 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL553635 | — | IC50 | = | 9.5 | nM | 8.02 |
| CHEMBL543303 | — | IC50 | = | 20.6 | nM | 7.69 |
| CHEMBL542105 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL545612 | TALLIMUSTINE CHLORIDE | IC50 | = | 68.5 | nM | 7.16 |
| CHEMBL852 | MELPHALAN | IC50 | = | 980.5 | nM | 6.01 |
| CHEMBL541041 | — | IC50 | > | 600.0 | nM | - |
| CHEMBL542354 | — | IC50 | > | 600.0 | nM | - |
| CHEMBL539768 | — | IC50 | > | 600.0 | nM | - |