Assay Detail
Functional
CHEMBL707312
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of LTB4 (LT) production in dog blood
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Canis lupus familiaris |
| Tissue | Blood |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Polyunsaturated fatty acid 5-lipoxygenase (CHEMBL215) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Indazolinones, a new series of redox-active 5-lipoxygenase inhibitors with built-in selectivity and oral activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.30 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3144583 | — | — | 1 | 6.70 |
| CHEMBL8429 | — | — | 1 | 6.52 |
| CHEMBL3144721 | — | — | 1 | 6.52 |
| CHEMBL276725 | — | — | 1 | 6.16 |
| CHEMBL3144579 | — | — | 1 | 6.10 |
| CHEMBL3144585 | — | — | 1 | 5.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3144583 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL8429 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL3144721 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL276725 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL3144579 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL3144585 | — | IC50 | = | 1500.0 | nM | 5.82 |