Assay Detail
Functional
CHEMBL707313
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of ionophore stimulated LTB4 release from human peripheral blood leukocytes.
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Polyunsaturated fatty acid 5-lipoxygenase (CHEMBL215) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Benzothiazole hydroxy ureas as inhibitors of 5-lipoxygenase: use of the hydroxyurea moiety as a replacement for hydroxamic acid.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 21 | 6.62 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL110928 | — | — | 1 | 7.70 |
| CHEMBL320274 | — | — | 1 | 7.70 |
| CHEMBL108204 | — | — | 1 | 7.41 |
| CHEMBL419745 | — | — | 1 | 7.35 |
| CHEMBL110863 | — | — | 1 | 7.16 |
| CHEMBL108854 | — | — | 1 | 7.16 |
| CHEMBL316040 | TEPOXALIN | 2.0 | 1 | 7.16 |
| CHEMBL108624 | — | — | 1 | 7.16 |
| CHEMBL320329 | — | — | 1 | 7.05 |
| CHEMBL325105 | — | — | 1 | 6.96 |
| CHEMBL320030 | — | — | 1 | 6.89 |
| CHEMBL110242 | — | — | 1 | 6.89 |
| CHEMBL106206 | — | — | 1 | 6.80 |
| CHEMBL110327 | — | — | 1 | 6.41 |
| CHEMBL93 | ZILEUTON | 4.0 | 1 | 6.33 |
| CHEMBL319002 | — | — | 1 | 6.28 |
| CHEMBL110513 | — | — | 1 | 5.97 |
| CHEMBL323039 | — | — | 1 | 5.50 |
| CHEMBL320275 | — | — | 1 | 5.28 |
| CHEMBL274642 | BW-755C | — | 1 | 5.17 |
| CHEMBL108538 | — | — | 1 | 4.61 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL110928 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL320274 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL108204 | — | EC50 | = | 39.0 | nM | 7.41 |
| CHEMBL419745 | — | EC50 | = | 45.0 | nM | 7.35 |
| CHEMBL110863 | — | EC50 | = | 70.0 | nM | 7.16 |
| CHEMBL108854 | — | EC50 | = | 70.0 | nM | 7.16 |
| CHEMBL316040 | TEPOXALIN | EC50 | = | 70.0 | nM | 7.16 |
| CHEMBL108624 | — | EC50 | = | 70.0 | nM | 7.16 |
| CHEMBL320329 | — | EC50 | = | 90.0 | nM | 7.05 |
| CHEMBL325105 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL320030 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL110242 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL106206 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL110327 | — | EC50 | = | 390.0 | nM | 6.41 |
| CHEMBL93 | ZILEUTON | EC50 | = | 470.0 | nM | 6.33 |
| CHEMBL319002 | — | EC50 | = | 530.0 | nM | 6.28 |
| CHEMBL110513 | — | EC50 | = | 1070.0 | nM | 5.97 |
| CHEMBL323039 | — | EC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL320275 | — | EC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL274642 | BW-755C | EC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL108538 | — | EC50 | = | 24500.0 | nM | 4.61 |