Assay Detail
Functional
CHEMBL707443
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Tested for transport into L1210 cells measured as cell influx
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Studies on analogues of classical antifolates bearing the naphthoyl group in place of benzoyl in the side chain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 5.97 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL134110 | — | — | 1 | 6.22 |
| CHEMBL337051 | — | — | 1 | 6.18 |
| CHEMBL136010 | — | — | 1 | 6.11 |
| CHEMBL134817 | — | — | 1 | 6.05 |
| CHEMBL335716 | — | — | 1 | 6.04 |
| CHEMBL132431 | — | — | 1 | 5.98 |
| CHEMBL341401 | — | — | 1 | 5.88 |
| CHEMBL132142 | — | — | 1 | 5.82 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 5.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL134110 | — | Ki | = | 600.0 | nM | 6.22 |
| CHEMBL337051 | — | Ki | = | 660.0 | nM | 6.18 |
| CHEMBL136010 | — | Ki | = | 780.0 | nM | 6.11 |
| CHEMBL134817 | — | Ki | = | 900.0 | nM | 6.05 |
| CHEMBL335716 | — | Ki | = | 920.0 | nM | 6.04 |
| CHEMBL132431 | — | Ki | = | 1040.0 | nM | 5.98 |
| CHEMBL341401 | — | Ki | = | 1310.0 | nM | 5.88 |
| CHEMBL132142 | — | Ki | = | 1520.0 | nM | 5.82 |
| CHEMBL34259 | METHOTREXATE | Ki | = | 3930.0 | nM | 5.41 |