Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL707508

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Tested against L1210 sensitive murine leukemia cells by MTT tetrazolium dye assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mus musculus
Cell Type L1210
Confidence 1 — Organism
Curated By Expert

Target

L1210 (CHEMBL386)
Type CELL-LINE
Organism Mus musculus

Publication

2-substituted 1,2-dihydro-3H-dibenz[de,h]isoquinoline-1,3-diones. A new class of antitumor agent.
Sami SM, Dorr RT, Alberts DS, Remers WA.
J Med Chem (1993) 36 : 765 -770
PubMed 8459403 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 20 6.74 8.15

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL290677 AZONAFIDE 1 8.15
CHEMBL423257 1 8.00
CHEMBL165018 1 7.84
CHEMBL349402 1 7.75
CHEMBL166139 1 7.44
CHEMBL166257 1 7.29
CHEMBL348916 1 7.29
CHEMBL165977 1 7.27
CHEMBL351618 1 7.12
CHEMBL166129 1 6.76
CHEMBL351023 1 6.73
CHEMBL434285 1 6.68
CHEMBL165858 1 6.29
CHEMBL163792 1 6.26
CHEMBL428676 AMONAFIDE 3.0 1 6.20
CHEMBL166062 1 6.20
CHEMBL165170 1 6.10
CHEMBL164825 1 5.73
CHEMBL350519 1 5.19
CHEMBL166191 1 4.57

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL290677 AZONAFIDE IC50 = 7.0 nM 8.15
CHEMBL423257 IC50 = 10.0 nM 8.00
CHEMBL165018 IC50 = 14.5 nM 7.84
CHEMBL349402 IC50 = 18.0 nM 7.75
CHEMBL166139 IC50 = 36.0 nM 7.44
CHEMBL166257 IC50 = 51.0 nM 7.29
CHEMBL348916 IC50 = 51.0 nM 7.29
CHEMBL165977 IC50 = 54.0 nM 7.27
CHEMBL351618 IC50 = 76.0 nM 7.12
CHEMBL166129 IC50 = 174.0 nM 6.76
CHEMBL351023 IC50 = 187.0 nM 6.73
CHEMBL434285 IC50 = 207.0 nM 6.68
CHEMBL165858 IC50 = 512.0 nM 6.29
CHEMBL163792 IC50 = 544.0 nM 6.26
CHEMBL428676 AMONAFIDE IC50 = 625.0 nM 6.20
CHEMBL166062 IC50 = 635.0 nM 6.20
CHEMBL165170 IC50 = 791.0 nM 6.10
CHEMBL164825 IC50 = 1872.0 nM 5.73
CHEMBL350519 IC50 = 6443.0 nM 5.19
CHEMBL166191 IC50 = 26738.0 nM 4.57