Assay Detail
Functional
CHEMBL707516
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Concentration required to inhibit 50% growth of L1210 mouse leukemia cells was determined
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Quinazoline antifolate thymidylate synthase inhibitors: 2'-fluoro-N10-propargyl-5,8-dideazafolic acid and derivatives with modifications in the C2 position.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.18 | 7.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL169981 | — | — | 1 | 7.57 |
| CHEMBL434209 | — | — | 1 | 7.07 |
| CHEMBL420280 | — | — | 1 | 6.54 |
| CHEMBL103059 | — | — | 1 | 6.44 |
| CHEMBL105026 | — | — | 1 | 6.00 |
| CHEMBL104230 | — | — | 1 | 5.96 |
| CHEMBL265098 | — | — | 1 | 5.72 |
| CHEMBL104410 | — | — | 1 | 5.72 |
| CHEMBL389051 | — | — | 1 | 5.46 |
| CHEMBL321977 | — | — | 1 | 5.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL169981 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL434209 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL420280 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL103059 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL105026 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL104230 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL265098 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL104410 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL389051 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL321977 | — | IC50 | = | 5000.0 | nM | 5.30 |