Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL707517

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
In vitro inhibition of L1210 mouse leukemia cell growth in culture
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mus musculus
Cell Type L1210
Confidence 1 — Organism
Curated By Expert

Target

L1210 (CHEMBL386)
Type CELL-LINE
Organism Mus musculus

Publication

Quinoline antifolate thymidylate synthase inhibitors: variation of the C2- and C4-substituents.
Warner P, Barker AJ, Jackman AL, Burrows KD, Roberts N, Bishop JA, O'Connor BM, Hughes LR.
J Med Chem (1992) 35 : 2761 -2768
PubMed 1495009 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 31 5.04 6.38

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL96367 1 6.38
CHEMBL93048 1 6.00
CHEMBL93037 1 6.00
CHEMBL545485 1 5.54
CHEMBL389051 1 5.47
CHEMBL92599 1 5.40
CHEMBL92246 1 5.10
CHEMBL92014 1 5.10
CHEMBL328173 1 4.96
CHEMBL330103 1 4.85
CHEMBL96551 1 4.64
CHEMBL93086 1 4.62
CHEMBL93098 1 4.52
CHEMBL96343 1 4.12
CHEMBL92445 1 4.00
CHEMBL91743 1 4.00
CHEMBL431846 1 -
CHEMBL92944 1 -
CHEMBL92341 1 -
CHEMBL432828 1 -
CHEMBL313846 1 -
CHEMBL96656 1 -
CHEMBL411036 1 -
CHEMBL96911 1 -
CHEMBL96355 1 -
CHEMBL328938 1 -
CHEMBL96086 1 -
CHEMBL328247 1 -
CHEMBL329543 1 -
CHEMBL318292 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL96367 IC50 = 420.0 nM 6.38
CHEMBL93048 IC50 = 1000.0 nM 6.00
CHEMBL93037 IC50 = 1000.0 nM 6.00
CHEMBL545485 IC50 = 2900.0 nM 5.54
CHEMBL389051 IC50 = 3400.0 nM 5.47
CHEMBL92599 IC50 = 4000.0 nM 5.40
CHEMBL92246 IC50 = 8000.0 nM 5.10
CHEMBL92014 IC50 = 8000.0 nM 5.10
CHEMBL328173 IC50 = 11000.0 nM 4.96
CHEMBL330103 IC50 = 14000.0 nM 4.85
CHEMBL96551 IC50 = 23000.0 nM 4.64
CHEMBL93086 IC50 = 24000.0 nM 4.62
CHEMBL93098 IC50 = 30000.0 nM 4.52
CHEMBL96343 IC50 = 75000.0 nM 4.12
CHEMBL92445 IC50 = 100000.0 nM 4.00
CHEMBL91743 IC50 = 100000.0 nM 4.00
CHEMBL431846 IC50 > 100000.0 nM -
CHEMBL92944 IC50 > 100000.0 nM -
CHEMBL92341 IC50 > 100000.0 nM -
CHEMBL432828 IC50 > 100000.0 nM -
CHEMBL313846 IC50 > 100000.0 nM -
CHEMBL96656 IC50 > 100000.0 nM -
CHEMBL411036 IC50 > 100000.0 nM -
CHEMBL96911 IC50 > 100000.0 nM -
CHEMBL96355 IC50 > 100000.0 nM -
CHEMBL328938 IC50 > 100000.0 nM -
CHEMBL96086 IC50 > 100000.0 nM -
CHEMBL328247 IC50 > 100000.0 nM -
CHEMBL329543 IC50 > 100000.0 nM -
CHEMBL318292 IC50 > 100000.0 nM -
CHEMBL327692 IC50 > 100000.0 nM -