Assay Detail
Functional
CHEMBL707543
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Effective dose for [3H]- estradiol against proliferation of MCF-7 cells
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Effect of triphenylacrylonitrile derivatives on estradiol-receptor binding and on human breast cancer cell growth.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 32 | 9.36 | 10.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL279301 | — | — | 1 | 10.80 |
| CHEMBL63877 | — | — | 1 | 10.70 |
| CHEMBL135 | ESTRADIOL | 4.0 | 1 | 10.70 |
| CHEMBL66352 | — | — | 1 | 10.52 |
| CHEMBL2137046 | — | — | 1 | 10.52 |
| CHEMBL63835 | — | — | 1 | 10.44 |
| CHEMBL65053 | — | — | 1 | 10.23 |
| CHEMBL294051 | — | — | 1 | 10.20 |
| CHEMBL63922 | — | — | 1 | 10.04 |
| CHEMBL293174 | — | — | 1 | 9.98 |
| CHEMBL83 | TAMOXIFEN | 4.0 | 1 | 9.96 |
| CHEMBL417964 | — | — | 1 | 9.92 |
| CHEMBL293234 | — | — | 1 | 9.85 |
| CHEMBL308006 | — | — | 1 | 9.85 |
| CHEMBL65427 | — | — | 1 | 9.74 |
| CHEMBL303987 | — | — | 1 | 9.72 |
| CHEMBL65499 | — | — | 1 | 9.72 |
| CHEMBL64910 | — | — | 1 | 9.70 |
| CHEMBL302647 | — | — | 1 | 9.55 |
| CHEMBL68236 | — | — | 1 | 9.55 |
| CHEMBL303801 | — | — | 1 | 9.40 |
| CHEMBL291639 | — | — | 1 | 9.38 |
| CHEMBL305128 | — | — | 1 | 9.26 |
| CHEMBL6619 | — | — | 1 | 8.35 |
| CHEMBL65179 | — | — | 1 | 8.30 |
| CHEMBL300460 | — | — | 1 | 7.96 |
| CHEMBL64918 | — | — | 1 | 7.92 |
| CHEMBL67727 | — | — | 1 | 7.85 |
| CHEMBL302528 | — | — | 1 | 7.60 |
| CHEMBL305168 | — | — | 1 | 7.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL279301 | — | EC50 | = | 0.016 | nM | 10.80 |
| CHEMBL63877 | — | EC50 | = | 0.02 | nM | 10.70 |
| CHEMBL135 | ESTRADIOL | EC50 | = | 0.02 | nM | 10.70 |
| CHEMBL66352 | — | EC50 | = | 0.03 | nM | 10.52 |
| CHEMBL2137046 | — | EC50 | = | 0.03 | nM | 10.52 |
| CHEMBL63835 | — | EC50 | = | 0.036 | nM | 10.44 |
| CHEMBL65053 | — | EC50 | = | 0.059 | nM | 10.23 |
| CHEMBL294051 | — | EC50 | = | 0.063 | nM | 10.20 |
| CHEMBL63922 | — | EC50 | = | 0.091 | nM | 10.04 |
| CHEMBL293174 | — | EC50 | = | 0.105 | nM | 9.98 |
| CHEMBL83 | TAMOXIFEN | EC50 | = | 0.11 | nM | 9.96 |
| CHEMBL417964 | — | EC50 | = | 0.12 | nM | 9.92 |
| CHEMBL293234 | — | EC50 | = | 0.14 | nM | 9.85 |
| CHEMBL308006 | — | EC50 | = | 0.14 | nM | 9.85 |
| CHEMBL65427 | — | EC50 | = | 0.18 | nM | 9.74 |
| CHEMBL65499 | — | EC50 | = | 0.19 | nM | 9.72 |
| CHEMBL303987 | — | EC50 | = | 0.19 | nM | 9.72 |
| CHEMBL64910 | — | EC50 | = | 0.2 | nM | 9.70 |
| CHEMBL302647 | — | EC50 | = | 0.28 | nM | 9.55 |
| CHEMBL68236 | — | EC50 | = | 0.28 | nM | 9.55 |
| CHEMBL303801 | — | EC50 | = | 0.4 | nM | 9.40 |
| CHEMBL291639 | — | EC50 | = | 0.42 | nM | 9.38 |
| CHEMBL305128 | — | EC50 | = | 0.55 | nM | 9.26 |
| CHEMBL6619 | — | EC50 | = | 4.5 | nM | 8.35 |
| CHEMBL65179 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL300460 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL64918 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL67727 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL302528 | — | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL305168 | — | EC50 | = | 28.0 | nM | 7.55 |
| CHEMBL303857 | — | EC50 | = | 44.0 | nM | 7.36 |
| CHEMBL304867 | — | EC50 | = | 102.0 | nM | 6.99 |