Assay Detail
Functional
CHEMBL707582
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Inhibitory concentration against MCF-7 breast tumor cells using MCF-7 assay.
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Estrogen receptor modulators: identification and structure-activity relationships of potent ERalpha-selective tetrahydroisoquinoline ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 8.12 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1116 | RALOXIFENE HYDROCHLORIDE | 4.0 | 1 | 8.85 |
| CHEMBL328388 | — | — | 1 | 8.70 |
| CHEMBL100617 | — | — | 1 | 8.70 |
| CHEMBL2113354 | — | — | 1 | 8.64 |
| CHEMBL98470 | — | — | 1 | 8.49 |
| CHEMBL100231 | — | — | 1 | 8.47 |
| CHEMBL101997 | — | — | 1 | 8.46 |
| CHEMBL319211 | — | — | 1 | 8.42 |
| CHEMBL174502 | — | — | 1 | 8.40 |
| CHEMBL101807 | — | — | 1 | 8.40 |
| CHEMBL327515 | — | — | 1 | 8.39 |
| CHEMBL103294 | — | — | 1 | 8.28 |
| CHEMBL328810 | — | — | 1 | 8.22 |
| CHEMBL101083 | — | — | 1 | 8.22 |
| CHEMBL100763 | — | — | 1 | 8.21 |
| CHEMBL319678 | — | — | 1 | 8.15 |
| CHEMBL103305 | — | — | 1 | 8.10 |
| CHEMBL2137046 | — | — | 1 | 8.07 |
| CHEMBL100595 | — | — | 1 | 7.57 |
| CHEMBL316080 | — | — | 1 | 7.54 |
| CHEMBL101382 | — | — | 1 | 7.50 |
| CHEMBL323119 | — | — | 1 | 7.50 |
| CHEMBL101719 | — | — | 1 | 7.44 |
| CHEMBL83 | TAMOXIFEN | 4.0 | 1 | 6.24 |
| CHEMBL103650 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1116 | RALOXIFENE HYDROCHLORIDE | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL328388 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL100617 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2113354 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL98470 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL100231 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL101997 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL319211 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL174502 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL101807 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL327515 | — | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL103294 | — | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL328810 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL101083 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL100763 | — | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL319678 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL103305 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL2137046 | — | IC50 | = | 8.5 | nM | 8.07 |
| CHEMBL100595 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL316080 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL101382 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL323119 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL101719 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL83 | TAMOXIFEN | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL103650 | — | IC50 | > | 1000.0 | nM | - |