Assay Detail
Functional
CHEMBL707589
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of 17-beta-estradiol induced MCF-7 cell proliferation
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Photochemical synthesis of N-arylbenzophenanthridine selective estrogen receptor modulators (serms).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 8.36 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1116 | RALOXIFENE HYDROCHLORIDE | 4.0 | 1 | 9.70 |
| CHEMBL280427 | — | — | 1 | 9.40 |
| CHEMBL316965 | — | — | 1 | 9.30 |
| CHEMBL12987 | — | — | 1 | 9.00 |
| CHEMBL319602 | — | — | 1 | 7.72 |
| CHEMBL97364 | — | — | 1 | 6.89 |
| CHEMBL97397 | — | — | 1 | 6.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1116 | RALOXIFENE HYDROCHLORIDE | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL280427 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL316965 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL12987 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL319602 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL97364 | — | IC50 | = | 128.0 | nM | 6.89 |
| CHEMBL97397 | — | IC50 | = | 287.0 | nM | 6.54 |