Assay Detail
Functional
CHEMBL707712
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Potency tested against multidrug resistance (MDR) cell lines expressing P-gp (P-glycoprotein)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | MDR |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Reversal of P-glycoprotein mediated multidrug resistance by novel anthranilamide derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 7.65 | 7.79 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL348475 | TARIQUIDAR | 3.0 | 1 | 7.79 |
| CHEMBL347245 | — | — | 1 | 7.72 |
| CHEMBL265750 | — | — | 1 | 7.57 |
| CHEMBL444075 | — | — | 1 | 7.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL348475 | TARIQUIDAR | EC50 | = | 16.3 | nM | 7.79 |
| CHEMBL347245 | — | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL265750 | — | EC50 | = | 27.0 | nM | 7.57 |
| CHEMBL444075 | — | EC50 | = | 30.0 | nM | 7.52 |