Assay Detail
Functional
CHEMBL707713
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for its inhibitory effect on the growth of MKN-45 tumor cell line from stomach.
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MKN-45 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Nucleosides and nucleotides. 152. 1-(3-C-Ethynyl--D-ribo-pentofuranosyl)uracil as a broad spectrum antitumor nucleoside
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.55 | 7.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL317514 | — | — | 1 | 7.62 |
| CHEMBL54918 | 5-FLUOROURIDINE | 2.0 | 1 | 7.58 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 5.52 |
| CHEMBL917 | FLOXURIDINE | 4.0 | 1 | 5.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL317514 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL54918 | 5-FLUOROURIDINE | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL917 | FLOXURIDINE | IC50 | = | 3500.0 | nM | 5.46 |