Assay Detail
Functional
CHEMBL707752
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Inhibitory activity against MDA-231 cell line using MTT assay (ER-,EGFR+,mutant p53)
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Antitumor polycyclic acridines. 7. Synthesis and biological properties of DNA affinic tetra- and pentacyclic acridines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.41 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 8.22 |
| CHEMBL43 | AMSACRINE | 4.0 | 1 | 6.85 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 6.82 |
| CHEMBL43453 | — | — | 1 | 6.72 |
| CHEMBL41700 | — | — | 1 | 6.64 |
| CHEMBL41526 | — | — | 1 | 6.27 |
| CHEMBL38451 | — | — | 1 | 6.26 |
| CHEMBL43229 | — | — | 1 | 6.02 |
| CHEMBL41174 | — | — | 1 | 5.76 |
| CHEMBL291263 | — | — | 1 | 5.69 |
| CHEMBL41863 | — | — | 1 | 5.26 |
| CHEMBL41701 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL43 | AMSACRINE | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL43453 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL41700 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL41526 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL38451 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL43229 | — | IC50 | = | 960.0 | nM | 6.02 |
| CHEMBL41174 | — | IC50 | = | 1730.0 | nM | 5.76 |
| CHEMBL291263 | — | IC50 | = | 2050.0 | nM | 5.69 |
| CHEMBL41863 | — | IC50 | = | 5450.0 | nM | 5.26 |
| CHEMBL41701 | — | IC50 | > | 10000.0 | nM | - |