Assay Detail
Functional
CHEMBL707792
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro cytotoxicity of compound against human MCF-7-MDR (breast) cancer cell line after 72 hr of drug exposure
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI/ADR-RES |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Tumor-specific novel taxoid-monoclonal antibody conjugates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.27 | 8.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL126678 | — | — | 1 | 8.66 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 6.63 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 6.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL126678 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 235.0 | nM | 6.63 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 299.0 | nM | 6.52 |