Assay Detail
Functional
CHEMBL707794
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Cytotoxicity was evaluated at 1 uM concentration in MCF7-R cell line when co-administered with Paclitaxel
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7R |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
New taxanes as highly efficient reversal agents for multidrug resistance in cancer cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.95 | 8.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL216610 | — | — | 1 | 8.59 |
| CHEMBL299712 | — | — | 1 | 7.68 |
| CHEMBL278218 | — | — | 1 | 7.48 |
| CHEMBL262004 | — | — | 1 | 7.44 |
| CHEMBL301615 | — | — | 1 | 7.38 |
| CHEMBL58623 | — | — | 1 | 7.00 |
| CHEMBL291911 | — | — | 1 | 6.80 |
| CHEMBL386475 | — | — | 1 | 6.33 |
| CHEMBL58284 | — | — | 1 | 6.30 |
| CHEMBL60766 | — | — | 1 | 6.27 |
| CHEMBL299041 | — | — | 1 | 6.07 |
| CHEMBL413204 | — | — | 1 | 6.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL216610 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL299712 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL278218 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL262004 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL301615 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL58623 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL291911 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL386475 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL58284 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL60766 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL299041 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL413204 | — | IC50 | = | 860.0 | nM | 6.07 |