Assay Detail
Functional
CHEMBL707795
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Cytotoxicity was evaluated at 3 uM concentration in MCF7-R cell line when co-administered with Paclitaxel
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7R |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
New taxanes as highly efficient reversal agents for multidrug resistance in cancer cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.43 | 8.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL60588 | — | — | 1 | 8.80 |
| CHEMBL298802 | — | — | 1 | 8.59 |
| CHEMBL293740 | — | — | 1 | 8.24 |
| CHEMBL409475 | — | — | 1 | 6.77 |
| CHEMBL264890 | — | — | 1 | 6.12 |
| CHEMBL384419 | — | — | 1 | 6.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL60588 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL298802 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL293740 | — | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL409475 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL264890 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL384419 | — | IC50 | = | 860.0 | nM | 6.07 |