Assay Detail

CHEMBL707797

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Functional

In vitro cytotoxicity against MCF7-R cell line

ChEMBL ↗

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Target

MCF7R (CHEMBL614327) ↗

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Primary target MCF7R

CHEMBL614327

Anchored from Assay target.

Protein identity MCF7R

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	MCF7R
Confidence	1 — Organism
Curated By	Intermediate

Target

MCF7R (CHEMBL614327) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Synthesis and biological evaluation of 2'-methyl taxoids derived from baccatin III and 14beta-OH-baccatin III 1,14-carbonate.

Battaglia A, Bernacki RJ, Bertucci C, Bombardelli E, Cimitan S, Ferlini C, Fontana G, Guerrini A, Riva A.
J Med Chem (2003) 46 : 4822 -4825
PubMed 14584931 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	6.98	7.44

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL382300	ORTATAXEL	2.0	1	7.44
CHEMBL428647	PACLITAXEL	4.0	1	6.52

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL382300	ORTATAXEL	IC50	=	36.0	nM	7.44
CHEMBL428647	PACLITAXEL	IC50	=	299.0	nM	6.52