Assay Detail
Functional
CHEMBL707798
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of the growth against human mammary carcinoma 180 fold resistant to doxorubicin (MCF-7-R) cell line after 72 hr exposure
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7R |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and structure-activity relationships of nonaromatic taxoids: effects of alkyl and alkenyl ester groups on cytotoxicity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.78 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL339531 | — | — | 1 | 7.92 |
| CHEMBL318368 | — | — | 1 | 7.58 |
| CHEMBL95734 | — | — | 1 | 7.42 |
| CHEMBL321365 | — | — | 1 | 7.24 |
| CHEMBL318914 | — | — | 1 | 6.85 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 6.63 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 6.52 |
| CHEMBL95487 | — | — | 1 | 6.38 |
| CHEMBL319735 | — | — | 1 | 6.35 |
| CHEMBL98348 | — | — | 1 | 6.23 |
| CHEMBL93429 | — | — | 1 | 6.23 |
| CHEMBL318400 | — | — | 1 | 5.97 |
| CHEMBL317148 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL339531 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL318368 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL95734 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL321365 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL318914 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 235.0 | nM | 6.63 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 299.0 | nM | 6.52 |
| CHEMBL95487 | — | IC50 | = | 412.0 | nM | 6.38 |
| CHEMBL319735 | — | IC50 | = | 446.0 | nM | 6.35 |
| CHEMBL98348 | — | IC50 | = | 591.0 | nM | 6.23 |
| CHEMBL93429 | — | IC50 | = | 589.0 | nM | 6.23 |
| CHEMBL318400 | — | IC50 | = | 1081.0 | nM | 5.97 |
| CHEMBL317148 | — | IC50 | > | 1000.0 | nM | - |