Assay Detail
Functional
CHEMBL707816
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity measured against MCF-7-mdr cells.
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Homocamptothecins: synthesis and antitumor activity of novel E-ring-modified camptothecin analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 8.15 | 11.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL358471 | — | — | 1 | 11.00 |
| CHEMBL345998 | — | — | 1 | 9.26 |
| CHEMBL150850 | — | — | 1 | 8.89 |
| CHEMBL348711 | — | — | 1 | 8.77 |
| CHEMBL149851 | — | — | 1 | 8.66 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 8.51 |
| CHEMBL151419 | — | — | 1 | 7.68 |
| CHEMBL84 | TOPOTECAN | 4.0 | 1 | 6.38 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 4.17 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL358471 | — | IC50 | = | 0.01 | nM | 11.00 |
| CHEMBL345998 | — | IC50 | = | 0.55 | nM | 9.26 |
| CHEMBL150850 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL348711 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL149851 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL151419 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL84 | TOPOTECAN | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 67000.0 | nM | 4.17 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 135000.0 | nM | - |