Assay Detail
Functional
CHEMBL707840
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Tested for cell growth inhibition against L1210 murine leukemia.
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Protein structure-based design, synthesis, and biological evaluation of 5-thia-2,6-diamino-4(3H)-oxopyrimidines: potent inhibitors of glycinamide ribonucleotide transformylase with potent cell growth inhibition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 6.73 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL84163 | — | — | 1 | 8.40 |
| CHEMBL85871 | — | — | 1 | 7.51 |
| CHEMBL309415 | — | — | 1 | 7.44 |
| CHEMBL315076 | — | — | 1 | 7.32 |
| CHEMBL82390 | — | — | 1 | 7.26 |
| CHEMBL315627 | — | — | 1 | 7.12 |
| CHEMBL84904 | — | — | 1 | 6.98 |
| CHEMBL85436 | — | — | 1 | 6.92 |
| CHEMBL85848 | — | — | 1 | 6.70 |
| CHEMBL84935 | — | — | 1 | 6.60 |
| CHEMBL84605 | — | — | 1 | 6.36 |
| CHEMBL82261 | — | — | 1 | 6.20 |
| CHEMBL84728 | — | — | 1 | 5.80 |
| CHEMBL82181 | — | — | 1 | 5.55 |
| CHEMBL84045 | — | — | 1 | 4.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL84163 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL85871 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL309415 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL315076 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL82390 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL315627 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL84904 | — | IC50 | = | 105.0 | nM | 6.98 |
| CHEMBL85436 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL85848 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL84935 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL84605 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL82261 | — | IC50 | = | 636.0 | nM | 6.20 |
| CHEMBL84728 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL82181 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL84045 | — | IC50 | = | 15000.0 | nM | 4.82 |