Assay Detail
Functional
CHEMBL708014
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Cytotoxicity in DFMO treated L1210 cell lines
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Defining the molecular requirements for the selective delivery of polyamine conjugates into cells containing active polyamine transporters.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.79 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL540552 | — | — | 1 | 6.82 |
| CHEMBL543610 | — | — | 1 | 6.70 |
| CHEMBL542751 | — | — | 1 | 6.44 |
| CHEMBL540336 | — | — | 1 | 6.37 |
| CHEMBL558813 | — | — | 1 | 6.16 |
| CHEMBL544167 | — | — | 1 | 5.64 |
| CHEMBL3216621 | — | — | 1 | 5.34 |
| CHEMBL558390 | — | — | 1 | 5.01 |
| CHEMBL3216180 | — | — | 1 | 4.77 |
| CHEMBL555288 | — | — | 1 | 4.66 |
| CHEMBL542262 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL540552 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL543610 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL542751 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL540336 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL558813 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL544167 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL3216621 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL558390 | — | IC50 | = | 9780.0 | nM | 5.01 |
| CHEMBL3216180 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL555288 | — | IC50 | = | 21900.0 | nM | 4.66 |
| CHEMBL542262 | — | IC50 | = | 421000.0 | nM | - |