Assay Detail
Functional
CHEMBL708153
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In vitro cytotoxicity of compounds were determined on murine leukemia cell line (L1210).
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and biological activity of aromatic amino acid phosphoramidates of 5-fluoro-2'-deoxyuridine and 1-beta-arabinofuranosylcytosine: evidence of phosphoramidase activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.13 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL917 | FLOXURIDINE | 4.0 | 1 | 7.92 |
| CHEMBL886 | 5-FLUORODEOXYURIDYLATE | — | 1 | 7.82 |
| CHEMBL1791078 | — | — | 1 | 6.40 |
| CHEMBL96148 | — | — | 1 | 6.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL917 | FLOXURIDINE | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL886 | 5-FLUORODEOXYURIDYLATE | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL1791078 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL96148 | — | IC50 | = | 410.0 | nM | 6.39 |