Assay Detail
Functional
CHEMBL708170
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In vitro photocytotoxicity is evaluated against human chronic myeloid leukemia cells grown in culture irradiated at 366 nM
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Panel leukemia (Carcinoma cell lines) |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
In vitro photoinduced cytotoxicity and DNA binding properties of psoralen and coumarin conjugates of netropsin analogues: DNA sequence-directed alkylation and cross-link formation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.88 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL280112 | — | — | 1 | 6.52 |
| CHEMBL277932 | — | — | 1 | 5.35 |
| CHEMBL278378 | — | — | 1 | 4.40 |
| CHEMBL20465 | — | — | 1 | 4.12 |
| CHEMBL416 | METHOXSALEN | 4.0 | 1 | 4.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL280112 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL277932 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL278378 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL20465 | — | IC50 | = | 75000.0 | nM | 4.12 |
| CHEMBL416 | METHOXSALEN | IC50 | = | 100000.0 | nM | 4.00 |