Assay Detail
Binding
CHEMBL708209
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Myosin light chain kinase 1 (MLCK1)
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Myosin light chain kinase, smooth muscle (CHEMBL2428) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and kinase inhibitory activity of 3'-(S)-epi-K-252a.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.63 | 7.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL281948 | K-252A | — | 1 | 7.66 |
| CHEMBL94678 | — | — | 1 | 7.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL281948 | K-252A | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL94678 | — | IC50 | = | 25.0 | nM | 7.60 |