Assay Detail
Functional
CHEMBL708352
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Compound was tested for antiproliferative activity against human MKN45 cancer cell lines
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MKN-45 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and biological evaluation of 3-(4-substituted-phenyl)-N-hydroxy-2-propenamides, a new class of histone deacetylase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.85 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL99 | TRICHOSTATIN | 1.0 | 1 | 7.00 |
| CHEMBL152543 | — | — | 1 | 6.10 |
| CHEMBL152133 | — | — | 1 | 6.08 |
| CHEMBL314389 | OXAMFLATIN | — | 1 | 5.97 |
| CHEMBL152538 | — | — | 1 | 5.53 |
| CHEMBL347068 | — | — | 1 | 5.44 |
| CHEMBL27759 | ENTINOSTAT | 3.0 | 1 | 5.38 |
| CHEMBL346525 | — | — | 1 | 5.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL99 | TRICHOSTATIN | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL152543 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL152133 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL314389 | OXAMFLATIN | IC50 | = | 1070.0 | nM | 5.97 |
| CHEMBL152538 | — | IC50 | = | 2940.0 | nM | 5.53 |
| CHEMBL347068 | — | IC50 | = | 3640.0 | nM | 5.44 |
| CHEMBL27759 | ENTINOSTAT | IC50 | = | 4160.0 | nM | 5.38 |
| CHEMBL346525 | — | IC50 | = | 4980.0 | nM | 5.30 |