Assay Detail
Functional
CHEMBL708381
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Anti-HIV activity against HIV-I IIIB strain in MT2 cell line
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MT2 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis, chromatographic resolution, and anti-human immunodeficiency virus activity of (+/-)-calanolide A and its enantiomers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 6.96 | 7.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 7.54 |
| CHEMBL267447 | CALANOLIDE A | 1.0 | 1 | 7.28 |
| CHEMBL282382 | — | — | 1 | 6.97 |
| CHEMBL853 | ZALCITABINE | 4.0 | 1 | 6.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 29.0 | nM | 7.54 |
| CHEMBL267447 | CALANOLIDE A | EC50 | = | 53.0 | nM | 7.28 |
| CHEMBL282382 | — | EC50 | = | 108.0 | nM | 6.97 |
| CHEMBL853 | ZALCITABINE | EC50 | = | 900.0 | nM | 6.05 |