Assay Detail
Functional
CHEMBL708385
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Concentration needed to inhibit HIV-1 virus replication in MT2 cells by 50% as determined by XTT assay.
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MT2 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
New series of potent, orally bioavailable, non-peptidic cyclic sulfones as HIV-1 protease inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 7.88 | 8.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL326764 | — | — | 1 | 8.19 |
| CHEMBL324071 | — | — | 1 | 8.05 |
| CHEMBL323814 | — | — | 1 | 7.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL326764 | — | EC50 | = | 6.5 | nM | 8.19 |
| CHEMBL324071 | — | EC50 | = | 9.0 | nM | 8.05 |
| CHEMBL323814 | — | EC50 | = | 40.0 | nM | 7.40 |