Assay Detail
Functional
CHEMBL708423
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The IC50 value was measured on LOX IMVI cell line in melanoma tumor ty
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | LOX IMVI |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Analogues of N alpha-(4-amino-4-deoxypteroyl)-N delta-hemiphthaloyl-L-ornithine (PT523) modified in the side chain: synthesis and biological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.45 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL18155 | — | — | 1 | 9.40 |
| CHEMBL42819 | — | — | 1 | 8.36 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 7.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL18155 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL42819 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 26.0 | nM | 7.58 |