Assay Detail
Functional
CHEMBL708499
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Inhibitory activity against human colon adenocarcinoma cell line LoVo/Dx.
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | LoVo |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Chromophore-modified antitumor anthracenediones: synthesis, DNA binding, and cytotoxic activity of 1,4-bis[(aminoalkyl)amino]benzo[g]-phthalazine-5,10-diones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.54 | 6.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL542514 | — | — | 1 | 6.36 |
| CHEMBL58 | MITOXANTRONE | 4.0 | 1 | 6.28 |
| CHEMBL150736 | — | — | 1 | 6.00 |
| CHEMBL150885 | — | — | 1 | 5.92 |
| CHEMBL149467 | — | — | 1 | 5.89 |
| CHEMBL356372 | — | — | 1 | 5.77 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 5.22 |
| CHEMBL542513 | — | — | 1 | 4.41 |
| CHEMBL49442 | AMETANTRONE | 2.0 | 1 | 4.04 |
| CHEMBL151165 | — | — | 1 | - |
| CHEMBL544168 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL542514 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL58 | MITOXANTRONE | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL150736 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL150885 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL149467 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL356372 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL542513 | — | IC50 | = | 39000.0 | nM | 4.41 |
| CHEMBL49442 | AMETANTRONE | IC50 | = | 92000.0 | nM | 4.04 |
| CHEMBL151165 | — | IC50 | > | 260000.0 | nM | - |
| CHEMBL544168 | — | IC50 | < | 2000.0 | nM | - |