Assay Detail
Binding
CHEMBL708549
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Inhibition of recombinant human matrix metalloprotease-3
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Structure--activity relationships of azasugar-based MMP/ADAM inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 7.93 | 9.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL61193 | — | — | 1 | 9.29 |
| CHEMBL92767 | — | — | 1 | 8.77 |
| CHEMBL327578 | — | — | 1 | 8.74 |
| CHEMBL93620 | — | — | 1 | 8.59 |
| CHEMBL90321 | — | — | 1 | 8.11 |
| CHEMBL419503 | — | — | 1 | 7.38 |
| CHEMBL279785 | MARIMASTAT | 3.0 | 1 | 7.08 |
| CHEMBL90806 | — | — | 1 | 7.07 |
| CHEMBL93720 | — | — | 1 | 6.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL61193 | — | Ki | = | 0.51 | nM | 9.29 |
| CHEMBL92767 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL327578 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL93620 | — | Ki | = | 2.6 | nM | 8.59 |
| CHEMBL90321 | — | Ki | = | 7.7 | nM | 8.11 |
| CHEMBL419503 | — | Ki | = | 42.0 | nM | 7.38 |
| CHEMBL279785 | MARIMASTAT | Ki | = | 84.0 | nM | 7.08 |
| CHEMBL90806 | — | Ki | = | 85.0 | nM | 7.07 |
| CHEMBL93720 | — | Ki | = | 490.0 | nM | 6.31 |