Assay Detail
Functional
CHEMBL708561
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Concentration required to inhibit growth of murine leukemia (L1210) cells in culture
22
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Potential antitumor agents. 54. Chromophore requirements for in vivo antitumor activity among the general class of linear tricyclic carboxamides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 5.91 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL88776 | — | — | 1 | 7.85 |
| CHEMBL37656 | — | — | 1 | 7.82 |
| CHEMBL163343 | — | — | 1 | 7.14 |
| CHEMBL9940 | — | — | 2 | 7.01 |
| CHEMBL57685 | — | — | 1 | 6.82 |
| CHEMBL61030 | — | — | 1 | 5.86 |
| CHEMBL160057 | — | — | 1 | 5.80 |
| CHEMBL125475 | — | — | 1 | 5.77 |
| CHEMBL164407 | — | — | 1 | 5.77 |
| CHEMBL162894 | — | — | 1 | 5.40 |
| CHEMBL159269 | — | — | 1 | 5.38 |
| CHEMBL163291 | — | — | 1 | 5.36 |
| CHEMBL163344 | — | — | 1 | 5.35 |
| CHEMBL350744 | — | — | 1 | 5.29 |
| CHEMBL162854 | — | — | 1 | 5.28 |
| CHEMBL164209 | — | — | 1 | 5.20 |
| CHEMBL354462 | — | — | 1 | 5.19 |
| CHEMBL349173 | — | — | 1 | 5.18 |
| CHEMBL160056 | — | — | 1 | - |
| CHEMBL349392 | — | — | 1 | - |
| CHEMBL9575 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL88776 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL37656 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL163343 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL9940 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL57685 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL61030 | — | IC50 | = | 1370.0 | nM | 5.86 |
| CHEMBL160057 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL125475 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL164407 | — | IC50 | = | 1715.0 | nM | 5.77 |
| CHEMBL162894 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL159269 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL163291 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL163344 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL350744 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL162854 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL164209 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL354462 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL349173 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL9940 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL160056 | — | IC50 | > | 22000.0 | nM | - |
| CHEMBL349392 | — | IC50 | > | 22000.0 | nM | - |
| CHEMBL9575 | — | IC50 | > | 25000.0 | nM | - |