Assay Detail
Binding
CHEMBL708592
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Compound tested for the inhibition of Escherichia coli Leucyl-tRNA synthetase
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity relationships of a series of novel thiazoles as inhibitors of aminoacyl-tRNA synthetases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.97 | 8.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL340082 | — | — | 1 | 8.80 |
| CHEMBL341331 | — | — | 1 | 8.22 |
| CHEMBL264002 | — | — | 1 | 6.00 |
| CHEMBL124856 | — | — | 1 | 4.85 |
| CHEMBL126919 | — | — | 1 | - |
| CHEMBL127892 | — | — | 1 | - |
| CHEMBL332104 | — | — | 1 | - |
| CHEMBL340488 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL340082 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL341331 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL264002 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL124856 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL126919 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL127892 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL332104 | — | IC50 | < | 2.0 | nM | - |
| CHEMBL340488 | — | IC50 | > | 100000.0 | nM | - |