Assay Detail
Binding
CHEMBL708593
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Compound tested for the inhibition of Staphylococcus aureus Leucyl-tRNA synthetase
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Staphylococcus aureus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Synthesis and structure-activity relationships of a series of novel thiazoles as inhibitors of aminoacyl-tRNA synthetases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.03 | 7.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL332104 | — | — | 1 | 7.05 |
| CHEMBL341331 | — | — | 1 | 7.00 |
| CHEMBL340082 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL332104 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL341331 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL340082 | — | IC50 | > | 54.0 | nM | - |