Assay Detail
Binding
CHEMBL708594
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Compound was evaluated for its inhibitory activity against Leucyl-tRNA synthetase from staphylococcus aureus WCUH29
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Staphylococcus aureus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Analogues of SB-203207 as inhibitors of tRNA synthetases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.42 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL421500 | — | — | 1 | 7.80 |
| CHEMBL74395 | — | — | 1 | 5.81 |
| CHEMBL74755 | — | — | 1 | 5.64 |
| CHEMBL74872 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL421500 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL74395 | — | IC50 | = | 1550.0 | nM | 5.81 |
| CHEMBL74755 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL74872 | — | IC50 | = | 186000.0 | nM | - |