Assay Detail
Binding
CHEMBL708598
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Compound tested for the inhibition of human Leucyl-tRNA synthetase
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity relationships of a series of novel thiazoles as inhibitors of aminoacyl-tRNA synthetases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.10 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL340082 | — | — | 1 | 6.22 |
| CHEMBL332104 | — | — | 1 | 6.14 |
| CHEMBL341331 | — | — | 1 | 5.94 |
| CHEMBL264002 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL340082 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL332104 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL341331 | — | IC50 | = | 1150.0 | nM | 5.94 |
| CHEMBL264002 | — | IC50 | = | 200000.0 | nM | - |