Assay Detail

CHEMBL708609

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Functional

Inhibition of LMM3 cell proliferation (derived from the BALB/c transplantable mammary adenocarcinoma MM3) in human

ChEMBL ↗

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Target

LMM3 cell line (CHEMBL614095) ↗

Open DB target context

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LMM3 cell line (CHEMBL614095) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target LMM3 cell line

CHEMBL614095

Anchored from Assay target.

Protein identity LMM3 cell line

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	LMM3
Confidence	1 — Organism
Curated By	Expert

Target

LMM3 cell line (CHEMBL614095) ↗

Type	CELL-LINE
Organism	Mus musculus

Publication

Meridianins, a new family of protein kinase inhibitors isolated from the ascidian Aplidium meridianum.

Gompel M, Leost M, De Kier Joffe EB, Puricelli L, Franco LH, Palermo J, Meijer L.
Bioorg Med Chem Lett (2004) 14 : 1703 -1704
PubMed 15026054 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	4.75	4.75

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL44545	MERIDIANIN B	—	1	4.75

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL44545	MERIDIANIN B	IC50	=	17700.0	nM	4.75