Assay Detail
Functional
CHEMBL708664
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Dose required to inhibit cell growth was determined against MDA-MB-231 cell line of human non-hormone dependent breast carcinoma
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Antimitotic antitumor agents: synthesis, structure-activity relationships, and biological characterization of N-aryl-N'-(2-chloroethyl)ureas as new selective alkylating agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 4.77 | 5.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL356033 | — | — | 1 | 5.60 |
| CHEMBL358165 | — | — | 1 | 5.51 |
| CHEMBL159697 | — | — | 1 | 5.30 |
| CHEMBL357489 | — | — | 1 | 5.24 |
| CHEMBL148690 | — | — | 1 | 5.21 |
| CHEMBL146303 | — | — | 1 | 5.21 |
| CHEMBL160114 | — | — | 1 | 5.14 |
| CHEMBL513 | CARMUSTINE | 4.0 | 1 | 5.13 |
| CHEMBL146268 | — | — | 1 | 5.05 |
| CHEMBL149175 | — | — | 1 | 5.00 |
| CHEMBL161784 | — | — | 1 | 5.00 |
| CHEMBL164268 | — | — | 1 | 4.92 |
| CHEMBL159887 | — | — | 1 | 4.82 |
| CHEMBL161374 | — | — | 1 | 4.75 |
| CHEMBL353576 | — | — | 1 | 4.72 |
| CHEMBL159809 | — | — | 1 | 4.70 |
| CHEMBL161012 | — | — | 1 | 4.62 |
| CHEMBL162017 | — | — | 1 | 4.60 |
| CHEMBL159599 | — | — | 1 | 4.57 |
| CHEMBL159685 | — | — | 1 | 4.52 |
| CHEMBL348741 | — | — | 1 | 4.51 |
| CHEMBL349619 | — | — | 1 | 4.50 |
| CHEMBL162027 | — | — | 1 | 4.48 |
| CHEMBL163103 | — | — | 1 | 4.47 |
| CHEMBL348361 | — | — | 1 | 4.36 |
| CHEMBL159544 | — | — | 1 | 4.30 |
| CHEMBL346689 | — | — | 1 | 4.28 |
| CHEMBL162350 | — | — | 1 | 4.22 |
| CHEMBL159393 | — | — | 1 | 4.12 |
| CHEMBL515 | CHLORAMBUCIL | 4.0 | 1 | 4.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL356033 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL358165 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL159697 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL357489 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL148690 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL146303 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL160114 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL513 | CARMUSTINE | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL146268 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL149175 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL161784 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL164268 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL159887 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL161374 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL353576 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL159809 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL161012 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL162017 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL159599 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL159685 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL348741 | — | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL349619 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL162027 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL163103 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL348361 | — | IC50 | = | 44000.0 | nM | 4.36 |
| CHEMBL159544 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL346689 | — | IC50 | = | 52000.0 | nM | 4.28 |
| CHEMBL162350 | — | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL159393 | — | IC50 | = | 76000.0 | nM | 4.12 |
| CHEMBL515 | CHLORAMBUCIL | IC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL160067 | — | IC50 | = | 140000.0 | nM | - |
| CHEMBL349708 | — | IC50 | = | 131000.0 | nM | - |
| CHEMBL348908 | — | IC50 | = | 150000.0 | nM | - |