Assay Detail
Functional
CHEMBL708784
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The IC50 was measured on L1210 cell lines incubated with compounds at concentration of 10 times the IC50 values and 10 uM thymidine 4
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Quinazoline antifolate thymidylate synthase inhibitors: replacement of glutamic acid in the C2-methyl series.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.09 | 4.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL269600 | — | — | 1 | 4.16 |
| CHEMBL266066 | — | — | 1 | 4.14 |
| CHEMBL269342 | — | — | 1 | 4.11 |
| CHEMBL268151 | — | — | 1 | 4.10 |
| CHEMBL264095 | — | — | 1 | 4.09 |
| CHEMBL6632 | — | — | 1 | 4.07 |
| CHEMBL6715 | — | — | 1 | 4.05 |
| CHEMBL267702 | — | — | 1 | 4.04 |
| CHEMBL6436 | — | — | 1 | 4.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL269600 | — | IC50 | = | 70000.0 | nM | 4.16 |
| CHEMBL266066 | — | IC50 | = | 72000.0 | nM | 4.14 |
| CHEMBL269342 | — | IC50 | = | 78000.0 | nM | 4.11 |
| CHEMBL268151 | — | IC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL264095 | — | IC50 | = | 82000.0 | nM | 4.09 |
| CHEMBL6632 | — | IC50 | = | 85000.0 | nM | 4.07 |
| CHEMBL6715 | — | IC50 | = | 90000.0 | nM | 4.05 |
| CHEMBL267702 | — | IC50 | = | 92000.0 | nM | 4.04 |
| CHEMBL6436 | — | IC50 | = | 98000.0 | nM | 4.01 |