Assay Detail
Functional
CHEMBL708788
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Concentration required to inhibit 50% growth of L1210 leukemia cells
44
Total Activities
44
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Cytotoxic activities of Mannich bases of chalcones and related compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 44 | 4.83 | 5.67 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL852 | MELPHALAN | 4.0 | 1 | 5.67 |
| CHEMBL555363 | — | — | 1 | 5.60 |
| CHEMBL557588 | — | — | 1 | 5.42 |
| CHEMBL8014 | — | — | 1 | 5.29 |
| CHEMBL545358 | — | — | 1 | 5.28 |
| CHEMBL557383 | — | — | 1 | 5.22 |
| CHEMBL542780 | — | — | 1 | 5.17 |
| CHEMBL545127 | — | — | 1 | 5.15 |
| CHEMBL266780 | — | — | 1 | 5.13 |
| CHEMBL538847 | — | — | 1 | 5.09 |
| CHEMBL552815 | — | — | 1 | 5.08 |
| CHEMBL545593 | — | — | 1 | 5.08 |
| CHEMBL555176 | — | — | 1 | 5.06 |
| CHEMBL7531 | — | — | 1 | 5.04 |
| CHEMBL545128 | — | — | 1 | 5.03 |
| CHEMBL7803 | — | — | 1 | 4.91 |
| CHEMBL8015 | — | — | 1 | 4.89 |
| CHEMBL7457 | — | — | 1 | 4.88 |
| CHEMBL7721 | — | — | 1 | 4.88 |
| CHEMBL8102 | — | — | 1 | 4.80 |
| CHEMBL536104 | — | — | 1 | 4.80 |
| CHEMBL542045 | — | — | 1 | 4.80 |
| CHEMBL544894 | — | — | 1 | 4.77 |
| CHEMBL537255 | — | — | 1 | 4.75 |
| CHEMBL7709 | — | — | 1 | 4.67 |
| CHEMBL276473 | 4'-HYDROXYCHALCONE | — | 1 | 4.63 |
| CHEMBL269163 | — | — | 1 | 4.61 |
| CHEMBL7973 | — | — | 1 | 4.61 |
| CHEMBL274303 | — | — | 1 | 4.60 |
| CHEMBL537011 | — | — | 1 | 4.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL852 | MELPHALAN | IC50 | = | 2130.0 | nM | 5.67 |
| CHEMBL555363 | — | IC50 | = | 2490.0 | nM | 5.60 |
| CHEMBL557588 | — | IC50 | = | 3830.0 | nM | 5.42 |
| CHEMBL8014 | — | IC50 | = | 5150.0 | nM | 5.29 |
| CHEMBL545358 | — | IC50 | = | 5280.0 | nM | 5.28 |
| CHEMBL557383 | — | IC50 | = | 5960.0 | nM | 5.22 |
| CHEMBL542780 | — | IC50 | = | 6840.0 | nM | 5.17 |
| CHEMBL545127 | — | IC50 | = | 7090.0 | nM | 5.15 |
| CHEMBL266780 | — | IC50 | = | 7320.0 | nM | 5.13 |
| CHEMBL538847 | — | IC50 | = | 8140.0 | nM | 5.09 |
| CHEMBL552815 | — | IC50 | = | 8290.0 | nM | 5.08 |
| CHEMBL545593 | — | IC50 | = | 8330.0 | nM | 5.08 |
| CHEMBL555176 | — | IC50 | = | 8730.0 | nM | 5.06 |
| CHEMBL7531 | — | IC50 | = | 9070.0 | nM | 5.04 |
| CHEMBL545128 | — | IC50 | = | 9320.0 | nM | 5.03 |
| CHEMBL7803 | — | IC50 | = | 12200.0 | nM | 4.91 |
| CHEMBL8015 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL7457 | — | IC50 | = | 13200.0 | nM | 4.88 |
| CHEMBL7721 | — | IC50 | = | 13100.0 | nM | 4.88 |
| CHEMBL8102 | — | IC50 | = | 15700.0 | nM | 4.80 |
| CHEMBL536104 | — | IC50 | = | 15900.0 | nM | 4.80 |
| CHEMBL542045 | — | IC50 | = | 15700.0 | nM | 4.80 |
| CHEMBL544894 | — | IC50 | = | 16900.0 | nM | 4.77 |
| CHEMBL537255 | — | IC50 | = | 17700.0 | nM | 4.75 |
| CHEMBL7709 | — | IC50 | = | 21200.0 | nM | 4.67 |
| CHEMBL276473 | 4'-HYDROXYCHALCONE | IC50 | = | 23500.0 | nM | 4.63 |
| CHEMBL269163 | — | IC50 | = | 24500.0 | nM | 4.61 |
| CHEMBL7973 | — | IC50 | = | 24700.0 | nM | 4.61 |
| CHEMBL274303 | — | IC50 | = | 25200.0 | nM | 4.60 |
| CHEMBL537011 | — | IC50 | = | 25800.0 | nM | 4.59 |
| CHEMBL7668 | — | IC50 | = | 29400.0 | nM | 4.53 |
| CHEMBL268559 | — | IC50 | = | 32200.0 | nM | 4.49 |
| CHEMBL536784 | — | IC50 | = | 32300.0 | nM | 4.49 |
| CHEMBL7575 | — | IC50 | = | 33800.0 | nM | 4.47 |
| CHEMBL274170 | — | IC50 | = | 33800.0 | nM | 4.47 |
| CHEMBL7747 | 4-HYDROXYCHALCONE | IC50 | = | 37900.0 | nM | 4.42 |
| CHEMBL266293 | — | IC50 | = | 39500.0 | nM | 4.40 |
| CHEMBL545130 | — | IC50 | = | 40100.0 | nM | 4.40 |
| CHEMBL7976 | CHALCONE | IC50 | = | 41400.0 | nM | 4.38 |
| CHEMBL8067 | — | IC50 | = | 46500.0 | nM | 4.33 |
| CHEMBL545595 | — | IC50 | = | 54000.0 | nM | 4.27 |
| CHEMBL7809 | — | IC50 | = | 265000.0 | nM | - |
| CHEMBL558976 | — | IC50 | = | 108000.0 | nM | - |
| CHEMBL440640 | — | IC50 | = | 395000.0 | nM | - |