Assay Detail
Functional
CHEMBL708791
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Tested for cytotoxicity against L1210 Leukemia cell
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Effect of A-ring modifications on the DNA-binding behavior and cytotoxicity of pyrrolo[2,1-c][1,4]benzodiazepines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.07 | 8.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL17192 | — | — | 1 | 8.43 |
| CHEMBL293096 | — | — | 1 | 6.42 |
| CHEMBL418651 | — | — | 1 | 5.82 |
| CHEMBL292689 | — | — | 1 | 5.62 |
| CHEMBL433491 | — | — | 1 | 5.57 |
| CHEMBL291815 | — | — | 1 | 5.57 |
| CHEMBL293119 | — | — | 1 | 5.57 |
| CHEMBL54666 | — | — | 1 | 5.52 |
| CHEMBL416315 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL17192 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL293096 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL418651 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL292689 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL433491 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL291815 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL293119 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL54666 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL416315 | — | IC50 | > | 100000.0 | nM | - |