Assay Detail
Functional
CHEMBL708809
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxic activity against mouse lymphocytic leukemia cells (L1210)
9
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis, spectroscopy, and cytotoxicity of glycosylated acetogenin derivatives as promising molecules for cancer therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 6.57 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3085422 | — | — | 2 | 8.00 |
| CHEMBL3085428 | — | — | 1 | 7.77 |
| CHEMBL3085425 | — | — | 1 | 7.30 |
| CHEMBL3085423 | — | — | 1 | 6.52 |
| CHEMBL3085424 | — | — | 1 | 5.00 |
| CHEMBL3085427 | — | — | 1 | 4.30 |
| CHEMBL41177 | SQUAMOCIN | — | 1 | - |
| CHEMBL43136 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3085422 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3085428 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL3085425 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3085422 | — | EC50 | = | 80.0 | nM | 7.10 |
| CHEMBL3085423 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL3085424 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL3085427 | — | EC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL41177 | SQUAMOCIN | EC50 | < | 0.25 | nM | - |
| CHEMBL43136 | — | EC50 | < | 0.4 | nM | - |