Assay Detail
Functional
CHEMBL708887
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Inhibition of growth of MCF-7 breast cancer cells in culture
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Cyclodextrin-derived diorganyl tellurides as glutathione peroxidase mimics and inhibitors of thioredoxin reductase and cancer cell growth.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.31 | 5.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL412348 | — | — | 1 | 5.85 |
| CHEMBL437864 | — | — | 1 | 5.80 |
| CHEMBL385299 | — | — | 1 | 5.34 |
| CHEMBL413290 | — | — | 1 | 5.22 |
| CHEMBL440625 | — | — | 1 | 5.00 |
| CHEMBL411553 | — | — | 1 | 4.99 |
| CHEMBL217200 | — | — | 1 | 4.98 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL412348 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL437864 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL385299 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL413290 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL440625 | — | IC50 | = | 10100.0 | nM | 5.00 |
| CHEMBL411553 | — | IC50 | = | 10200.0 | nM | 4.99 |
| CHEMBL217200 | — | IC50 | = | 10400.0 | nM | 4.98 |