Assay Detail
Functional
CHEMBL708892
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Inhibitory activity against BrdU incorporation to MCF-7 cell line following 3 day exposure to compound
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Imidazo[1,2-a]pyridines. Part 2: SAR and optimisation of a potent and selective class of cyclin-dependent kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.65 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL72548 | — | — | 1 | 7.16 |
| CHEMBL71044 | — | — | 1 | 7.16 |
| CHEMBL308853 | — | — | 1 | 6.58 |
| CHEMBL309573 | — | — | 1 | 6.41 |
| CHEMBL70824 | — | — | 1 | 6.36 |
| CHEMBL73243 | — | — | 1 | 6.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL72548 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL71044 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL308853 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL309573 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL70824 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL73243 | — | IC50 | = | 600.0 | nM | 6.22 |