Assay Detail
Functional
CHEMBL708939
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro cytotoxicity using murine leukemia L1210 cells from american type culture collection.
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and biological activity of 4-azido- and 4-trifluoracetamido-3-chloro-3-deamino-4-deoxydaunorubicin
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.78 | 7.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL178 | DAUNORUBICIN | 4.0 | 1 | 7.48 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.48 |
| CHEMBL311371 | — | — | 1 | 6.30 |
| CHEMBL310208 | — | — | 1 | 5.86 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL178 | DAUNORUBICIN | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL311371 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL310208 | — | IC50 | = | 1370.0 | nM | 5.86 |