Assay Detail
Functional
CHEMBL708946
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for antitumor activity against Murine leukemia cell line (L1210).
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
2-[2'-(Dimethylamino)ethyl]-1,2-dihydro- 3H-dibenz[de,h]isoquinoline-1,3-diones with substituents at positions 4, 8, 9, 10, and 11. Synthesis, antitumor activity, and quantitative structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.61 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL146037 | — | — | 1 | 7.82 |
| CHEMBL345020 | — | — | 1 | 7.17 |
| CHEMBL422843 | — | — | 1 | 4.83 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL146037 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL345020 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL422843 | — | IC50 | = | 14825.0 | nM | 4.83 |