Assay Detail
Functional
CHEMBL708947
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitumor activity against sensitive L1210 murine leukemia cell lines.
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
2-[2'-(Dimethylamino)ethyl]-1,2-dihydro- 3H-dibenz[de,h]isoquinoline-1,3-diones with substituents at positions 4, 8, 9, 10, and 11. Synthesis, antitumor activity, and quantitative structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 7.30 | 8.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL148281 | — | — | 1 | 8.29 |
| CHEMBL356797 | — | — | 1 | 8.24 |
| CHEMBL290677 | AZONAFIDE | — | 1 | 8.15 |
| CHEMBL148344 | — | — | 1 | 8.11 |
| CHEMBL146785 | — | — | 1 | 8.09 |
| CHEMBL58 | MITOXANTRONE | 4.0 | 1 | 8.01 |
| CHEMBL146037 | — | — | 1 | 8.00 |
| CHEMBL149293 | — | — | 1 | 7.89 |
| CHEMBL147372 | — | — | 1 | 7.82 |
| CHEMBL422137 | — | — | 1 | 7.68 |
| CHEMBL343913 | — | — | 1 | 7.60 |
| CHEMBL147576 | — | — | 1 | 7.60 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.46 |
| CHEMBL356785 | — | — | 1 | 7.39 |
| CHEMBL439812 | — | — | 1 | 7.27 |
| CHEMBL345020 | — | — | 1 | 7.27 |
| CHEMBL147428 | — | — | 1 | 7.16 |
| CHEMBL358993 | — | — | 1 | 7.16 |
| CHEMBL146559 | — | — | 1 | 6.97 |
| CHEMBL146516 | — | — | 1 | 6.72 |
| CHEMBL439632 | — | — | 1 | 6.72 |
| CHEMBL343852 | — | — | 1 | 6.68 |
| CHEMBL149184 | — | — | 1 | 6.51 |
| CHEMBL428676 | AMONAFIDE | 3.0 | 1 | 6.20 |
| CHEMBL148229 | — | — | 1 | 5.75 |
| CHEMBL422843 | — | — | 1 | 5.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL148281 | — | IC50 | = | 5.1 | nM | 8.29 |
| CHEMBL356797 | — | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL290677 | AZONAFIDE | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL148344 | — | IC50 | = | 7.7 | nM | 8.11 |
| CHEMBL146785 | — | IC50 | = | 8.1 | nM | 8.09 |
| CHEMBL58 | MITOXANTRONE | IC50 | = | 9.7 | nM | 8.01 |
| CHEMBL146037 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL149293 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL147372 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL422137 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL343913 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL147576 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL356785 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL439812 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL345020 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL147428 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL358993 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL146559 | — | IC50 | = | 108.0 | nM | 6.97 |
| CHEMBL146516 | — | IC50 | = | 189.0 | nM | 6.72 |
| CHEMBL439632 | — | IC50 | = | 189.0 | nM | 6.72 |
| CHEMBL343852 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL149184 | — | IC50 | = | 312.0 | nM | 6.51 |
| CHEMBL428676 | AMONAFIDE | IC50 | = | 625.0 | nM | 6.20 |
| CHEMBL148229 | — | IC50 | = | 1779.0 | nM | 5.75 |
| CHEMBL422843 | — | IC50 | = | 6739.0 | nM | 5.17 |